Anderlecht
Anderlecht will be without Giulian Biancone for Lyon's visit, with the centre-back — substituted after just 37 minutes against KV Mechelen — sidelined until after the international break. Andrew Omobamidele is expected to replace him alongside Léo Pétrot in central defence.
Lukáš Ambros is a doubt after suffering a knock, having been substituted in all three of his recent starts. Marten Winkler made his first start of the last five matches when Ambros did not play against KV Mechelen and is set to keep his place on the right of midfield.
Lyon
Julien Duranville returned to collective training after three matches out, but was unavailable with a muscle injury for the trip to Paris FC.
Abner will not be an option either: the left-back has not been registered for Lyon's European squad rather than being injured. In goal, Dominik Greif is expected to start, although Rémy Descamps remains an alternative in one of several positions still up for grabs in Paulo Fonseca's side.
Mads Bidstrup has started all four matches this season but been substituted in every one, and Ernest Nuamah's three starts on the right have ended the same way. Further forward, Pavel Šulc and Corentin Tolisso have rotated in the attacking-midfield role with little between them, and both places remain unsettled against Anderlecht: Keito Nakamura is the alternative to Šulc, and Noah Nartey to Tolisso.
