RB Leipzig
Brajan Gruda is working his way back from an abdominal muscle problem and could return among the front three, with Nicolas Seiwald the alternative. Leipzig go into the game already without Marc Guiu and Assan Ouédraogo through injury.
Rômulo, who scored on his first league start against Bayer Leverkusen, is set to keep his place up front. Castello Lukeba and Maxime Esteve are the options in central defence alongside Willi Orban, while Christoph Baumgartner and Rocco Reitz remain out with thigh injuries.
Eintracht Frankfurt
Nnamdi Collins has been given the all-clear to return and is competing with Elias Baum for a place in defence. Jeremiaha Maluze is a doubt because of a thigh injury and missed the draw with Freiburg after starting twice in Frankfurt's last four matches.
Can Uzun declared himself fit this week after a recent thigh issue, though his involvement against Leipzig remains uncertain. Ritsu Doan is set to continue on the right of midfield after starting there twice to Ayoube Amaimouni's one in Frankfurt's last four matches.
Keita Kosugi keeps his place at left-back, having started in each of Frankfurt's last four matches, while Jessic Ngankam remains doubtful because of a hamstring problem.
